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KMID : 0388419990080020047
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Konkuk Journal of Medical Sciences
1999 Volume.8 No. 2 p.47 ~ p.57
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The Prevalence of Helicobacter pylori and the Effect of its Eradication on Clinical Symptoms in Patients with Functional Dyspepsia
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Song Kee-Ho
Jin Chun-Jo
Park Hyung-Seok
Lee Jae-Dong
Lee Su-In
Youn Ho-Sang
Kim Seog
Lee Sung-Cheorl
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Abstract
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This study was designed for the assessment of the prevalence of Helicobacter pylori and the effect of its eradication on clinical symptoms in patients with functional dyspepsia. We enrolled 51 patients with dyspepsia more than 3 months. The patients, who had no organic lesion in endoscopy into 4 group: A (Helicobacter pylori infected and eradication group), B (Helicobacter pylori infected and non-eradicated group), C (Helicobacter pylori not infected and proton-pump inhibitor and free radical scavenger administration group), and D (Helicobacter pylori not infected and free radical scavenger only group). And follow-up the patients on 10th day and 30th day, when we score the dyspeptic symptom and frequency. 24 out of 51(47.1%) were CLO positive. There were much improvements at 30th day dyspepsia score in eradicated group(A) but not in non-eradicated group. And the difference between two groups was statistically significant (p<0.001). There was no difference between group C and D. In conclusion, Helicobacter pylori has a role in functional dyspepsia and the eradication of Helicobacter pylori in patients with functional dyspepsia improve the clinical symptoms of dyspepsia.
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KEYWORD
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Helicobacter pylori, Functional dyspepsia, Eradication
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